Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold
- Author(s)
- Wan, Xiaoyu; Yap, Jiajun; Chen, Junjun; Li, Yifan; Faruk, Regina; Tan, Nazereth Chor Boon; Ma, Yiying; Lim, Yiting; Jubri, Karlina Bte; Hu, Jingyi; Yuan, Jimin; Zhang, Ge; Li, Quan; Yap, Yoon Sim; Lam, Paula; Wang, Mei; Fu, Nai Yang; Hu, Jiancheng;
- Details
- Publication Year 2025,Volume 15,Issue #5,Page 2035-2051
- Journal Title
- Theranostics
- Abstract
- The Ser/Thr kinase RAF, particularly BRAF isoform is a dominant target of oncogenic mutations and many mutations have been identified in various cancers. However, how these mutations except V600E evade the regulatory machinery of RAF protein and hence trigger its oncogenicity remains unclear.
- Publisher
- Ivyspring International Publisher
- Research Division(s)
- Cancer Biology And Stem Cells
- Publisher's Version
- https://doi.org/10.7150/thno.103958
- Open Access at Publisher's Site
https://doi.org/10.7150/thno.103958- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-02-07 02:57:20
Last Modified: 2025-02-07 03:13:23