An X-tra role for NFκB in gene regulation?
- Details
- Publication Year 2025-03,Volume 103,Issue #3,Page 220-223
- Journal Title
- Immunology & Cell Biology
- Abstract
- In this Research Highlight, we discuss recent research which shows that TCR-mediated activation and NF-κB signalling play an indispensable role in localising Xist RNA and its interactors to the inactive X chromosome (Xi) in T cells (left and middle). Inhibition of NF-κB disrupts this process, impairing the recruitment of silencing factors and jeopardizing the maintenance of X chromosome inactivation (right).
- Publisher
- Wiley
- Keywords
- *NF-kappa B/metabolism; Humans; Animals; *X Chromosome Inactivation/genetics; *RNA, Long Noncoding/genetics/metabolism; *Gene Expression Regulation; Signal Transduction; T-Lymphocytes/immunology/metabolism; Receptors, Antigen, T-Cell/metabolism; Nfκb; epigenetics; gene regulation
- Research Division(s)
- Immunology
- PubMed ID
- 39793998
- Publisher's Version
- https://doi.org/10.1111/imcb.12850
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-03-19 09:29:33
Last Modified: 2025-04-08 03:12:58