Advances in mitophagy initiation mechanisms
- Author(s)
- Küng, C; Lazarou, M; Nguyen, TN;
- Journal Title
- Current Opinion in Cell Biology
- Abstract
- Mitophagy is an important lysosomal degradative pathway that removes damaged or unwanted mitochondria to maintain cellular and organismal homeostasis. The mechanisms behind how mitophagy is initiated to form autophagosomes around mitochondria have gained a lot of interest since they can be potentially targeted by mitophagy-inducing therapeutics. Mitophagy initiation can be driven by various autophagy receptors or adaptors that respond to different cellular and mitochondrial stimuli, ranging from mitochondrial damage to metabolic rewiring. This review will cover recent advances in our understanding of how mitophagy is initiated, and by doing so reveal the mechanistic plasticity of how autophagosome formation can begin.
- Publisher
- Elsevier
- Research Division(s)
- Ubiquitin Signalling
- PubMed ID
- 40117675
- Publisher's Version
- https://doi.org/10.1016/j.ceb.2025.102493
- Open Access at Publisher's Site
https://doi.org/10.1016/j.ceb.2025.102493- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-04-08 02:51:04
Last Modified: 2025-04-08 03:12:51