Maternal Tmprss6 is required for hepcidin suppression and fetal health
- Author(s)
- Fielding, KL; Randall, L; Bennett, C; Martinez, A; Pettikiriarachchi, A; Ataíde, R; Jones, N; Harding, R; McLean, ARD; Schaeper, U; Pasricha, SR;
- Details
- Publication Year 2025-06-19,Volume 145,Issue #25,Page 3056-3059
- Journal Title
- Blood
- Abstract
- The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.
- Publisher
- Elsevier
- Keywords
- Female; *Hepcidins/metabolism/genetics; Pregnancy; *Serine Endopeptidases/genetics/metabolism/physiology; Animals; *Membrane Proteins/genetics/metabolism/physiology; Mice; Mice, Knockout; *Fetus/metabolism; Humans
- Research Division(s)
- Infection and Global Health
- PubMed ID
- 40233319
- Publisher's Version
- https://doi.org/10.1182/blood.2024027563
- Open Access at Publisher's Site
https://doi.org/10.1182/blood.2024027563.- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-05 08:40:16
Last Modified: 2025-09-23 11:10:34