Maternal Tmprss6 is required for hepcidin suppression and fetal health
- Author(s)
- Fielding, KL; Bennett, C; Pettikiriarachchi, A; Jones, N; Harding, R; McLean, ARD; Randall, LM; Schaeper, U; Martinez, APhD; Ataide, R; Pasricha, SR;
- Journal Title
- Blood
- Publication Type
- Apr 15
- Abstract
- The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated as knockout dams are infertile. Utilising an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.
- Publisher
- ASH
- Research Division(s)
- Infection and Global Health
- PubMed ID
- 40233319
- Publisher's Version
- https://doi.org/10.1182/blood.2024027563
- Open Access at Publisher's Site
https://doi.org/10.1182/blood.2024027563- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-05 08:40:16
Last Modified: 2025-05-05 08:40:35