DNA repair and the contribution to chemotherapy resistance
- Author(s)
- Nesic, K; Parker, P; Swisher, EM; Krais, JJ;
- Details
- Publication Year 2025-05-26,Volume 17,Issue #1,Page 62
- Journal Title
- Genome Medicine
- Abstract
- The DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in part, facilitates a therapeutic window for many chemotherapeutic agents whose mechanisms of action often converge at the generation of a double-strand DNA break. The development of therapy resistance occurs through countless molecular mechanisms that promote tolerance to DNA damage, often by preventing break formation or increasing repair capacity. This review broadly discusses the DNA damaging mechanisms of action for different classes of chemotherapeutics, how avoidance and repair of double-strand breaks can promote resistance, and strategic directions for counteracting therapy resistance.
- Publisher
- BMC
- Keywords
- Humans; *DNA Repair; *Drug Resistance, Neoplasm/genetics; *Neoplasms/drug therapy/genetics; *Antineoplastic Agents/pharmacology/therapeutic use; DNA Damage; Animals; DNA Breaks, Double-Stranded/drug effects; Chemotherapy resistance; DNA damage response; DNA repair
- Research Division(s)
- Cancer Biology And Stem Cells
- PubMed ID
- 40420317
- Publisher's Version
- https://doi.org/10.1186/s13073-025-01488-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-05-29 02:03:13
Last Modified: 2025-05-29 02:08:05