Biorepositories For Global Rare Disease Research: A Narrative Review

Pellico, MR; Day, J; Shah, M; Yi, BY; Saketkoo, LA; Lood, C; Gupta, L

Author(s): Pellico, MR; Day, J; Shah, M; Yi, BY; Saketkoo, LA; Lood, C; Gupta, L;
Details: Publication Year 2025-05-21,Volume 27,Issue #1,Page 24
Journal Title: Current Rheumatology Reports
Abstract: PURPOSE OF THIS REVIEW: Rare diseases, although individually infrequent, collectively impact a substantial number of people. Collaborative translational research using biospecimens is essential for advancing our understanding of the diverse characteristics and pathophysiology of rare diseases. Biobanks play a pivotal role in this endeavor by collecting, processing, transporting, and storing biospecimens, thereby serving as invaluable resources for medical research. In this review, we explore currently available biobanks, with a specific focus on those dedicated to rare rheumatic diseases. We also examine accessible best practice guidelines for establishing and maintaining high-quality biobanks, discuss the limitations and propose future directions for enhancing biobanking efforts in rare disease research. RECENT FINDINGS: Advances in molecular and genomic technologies have expanded the role of biobanks, enhancing biomarker discovery and precision medicine. However, despite growth in biobanking capabilities, key challenges persist concerning ethics, interoperability, and biospecimen exchange, prompting active responses by various regulatory and governing bodies. Biobanking has transformed rare disease research. Strengthening national and international collaborations is essential for driving progress in this field and accelerating the development of novel therapeutic and precision medicine approaches.
Publisher: Springer Nature
Keywords: Humans; *Rare Diseases; *Biological Specimen Banks; *Biomedical Research; Precision Medicine; Biobank; Biospecimen; Connective tissue disease; Myopathies; Myositis; Rare disease
Research Division(s): Inflammation
PubMed ID: 40397074
Publisher's Version: https://doi.org/10.1007/s11926-025-01189-6
Open Access at Publisher's Site: https://doi.org/10.1007/s11926-025-01189-6
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-05-29 02:03:15

Last Modified: 2025-05-29 02:08:05