Association of a Novel IgG3 Allele With Malaria in Children From the Sepik Region of Papua New Guinea

Saeed, M; Aitken, EH; Naung, MT; Bourke, C; Wu, KW; Longley, RJ; Chung, AW; Damelang, T; Kiniboro, B; Mueller, I; Rogerson, SJ

Author(s): Saeed, M; Aitken, EH; Naung, MT; Bourke, C; Wu, KW; Longley, RJ; Chung, AW; Damelang, T; Kiniboro, B; Mueller, I; Rogerson, SJ;
Details: Publication Year 2025-10-15,Volume 232,Issue #4,Page e555-e564
Journal Title: Journal of Infectious Diseass
Abstract: BACKGROUND: Susceptibility to malaria can be influenced by host genetic factors, including immune response genes. Antibodies against Plasmodium antigens are known to play an important role in protection from clinical disease. Polymorphisms in these antibodies may result in different functional properties that could provide protection from malaria. METHODS: Immunoglobulin G1 (IgG1) and immunoglobulin G3 (IgG3) alleles and IgG3 hinge region were investigated by polymerase chain reaction and Sanger sequencing in a longitudinal cohort of children aged 1-3 years (N = 203) from the East Sepik region of Papua New Guinea. Linear regression was used to investigate associations between immunoglobulin alleles and Plasmodium infections. RESULTS: Seventy-eight percent of the children were either heterozygous (n = 82 [40%]) or homozygous (n = 77 [38%]) for IGHG3*30 (G3m29), a novel IgG3 allele. G3m29 has a long hinge region of 4 exons. Significantly fewer Plasmodium spp infections were observed in children with the IGHG3*30 allele compared to children without the allele (beta = -1.736 [95% confidence interval CI, -3.39, -.079]; P = .038). This effect was most noticeable for Plasmodium vivax asymptomatic infections as IGHG3*30 carriers had on average 1 fewer infection in the 18-month follow-up period compared with non-IGHG3*30 allele carriers (beta = -1.06 [95% CI, -2.01, -.12]; P = .028). Additionally, IGHG3*30 allele carriers had significantly lower levels of IgG to P vivax vaccine candidate proteins compared to non-IGHG3*30 allele carriers. CONCLUSIONS: The IGHG3*30 allele is highly prevalent in the East Sepik region and is associated with fewer Plasmodium spp infections.
Publisher: Oxford Academic
Keywords: Humans; Papua New Guinea/epidemiology; Child, Preschool; Infant; *Immunoglobulin G/genetics; Alleles; Male; Female; Longitudinal Studies; *Malaria/genetics/immunology/epidemiology; Antibodies, Protozoan/genetics/blood; *Genetic Predisposition to Disease; Malaria, Vivax/genetics/immunology; P falciparum; P vivax; IgG3 polymorphism; antibody; malaria
Research Division(s): Infection and Global Health
PubMed ID: 40717585
Publisher's Version: https://doi.org/10.1093/infdis/jiaf390
Open Access at Publisher's Site: https://doi.org/10.1093/infdis/jiaf390
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-08-08 03:14:12

Last Modified: 2025-10-20 01:59:39