Enterocolitis associated with glofitamab-First report and clinicopathological findings in three cases

McKeague, S; Robertson, M; van der Linde, S; Khoo, C; Segal, J; Harrop, S; Minson, A; Roberts, AW; Dickinson, M

Author(s): McKeague, S; Robertson, M; van der Linde, S; Khoo, C; Segal, J; Harrop, S; Minson, A; Roberts, AW; Dickinson, M;
Details: Publication Year 2025-06,Volume 206,Issue #6,Page 1654-1658
Journal Title: British Journal of Cancer
Abstract: Glofitamab is a CD3-CD20 bispecific antibody used to treat B-cell non-Hodgkin lymphoma. We describe three cases of enterocolitis occurring with glofitamab at a single institution. Similarities between cases include onset post cycle 4-5, moderately elevated faecal calprotectin, abnormal bowel avidity on positron emission tomography scan (2/3), absence of CD20-positive B cells on gut histology and steroid responsiveness. There was variability in the area of gastrointestinal inflammation, severity of symptoms, histological findings and impact on subsequent therapy. The mechanism for this phenomenon is unknown. Possible explanations include B-regulatory cell depletion and T-cell recruitment to the gastrointestinal tract because of CD20 antigen density. Clinicians should consider this toxicity in glofitamab-treated patients presenting with sustained diarrhoea or abdominal pain when infectious colitis has been comprehensively excluded.
Publisher: Wiley
Keywords: Humans; Male; Female; *Enterocolitis/chemically induced/pathology/diagnostic imaging; Aged; Middle Aged; *Antibodies, Bispecific/adverse effects/administration & dosage; T cells; drug antibodies; drugs; immune; lymphoid malignancies; lymphomas
Research Division(s): Blood Cells and Blood Cancer
PubMed ID: 40108860
Publisher's Version: https://doi.org/10.1111/bjh.20052
Open Access at Publisher's Site: https://doi.org/10.1111/bjh.20052
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-08-19 01:46:03

Last Modified: 2025-08-19 01:46:21