Mapping lung cancer ventilation dynamics: A pilot mouse study using functional imaging and lung mechanics
- Author(s)
- Smith, R; Reyne, N; Batey, D; Eikelis, N; Asselin Labat, ML; Donnelley, M;
- Journal Title
- Disease Models & Mechanisms
- Publication Type
- Oct 28
- Abstract
- In vivo models that replicate and reproduce human lung cancer and its response to therapy are necessary for the development of new therapeutic strategies and understanding drug resistance. Imaging lung tumors in live animals to monitor tumor growth and response to therapy is challenging due to the location of the lungs and their constant movement during breathing. X-ray velocimetry (XV) is a novel functional lung imaging technique that maps regional lung expansion during breathing, providing spatial information on where ventilation changes occur. The aim of this pilot study was to use XV and flexiVent lung mechanics assessments to determine the effect of tumor growth on lung function in mice at 2- or 3-weeks post tumor induction, and to evaluate the efficacy of these two tools. Histological analysis showed that tumour growth was not uniform between animals. At 3-weeks post tumor induction, some XV ventilation and flexiVent lung mechanics parameters were significantly different from baseline. Both techniques gave metrics which correlated with the tumour counts from the histology. In some mice XV revealed localised regions with altered expansion rates.
- Publisher
- COB
- Keywords
- Animal models; FlexiVent; Lung cancer; Lung disease; Lung function; Permetium; X-ray Velocimetry
- Research Division(s)
- Personalised Oncology
- PubMed ID
- 41146618
- Publisher's Version
- https://doi.org/10.1242/dmm.052559
- Open Access at Publisher's Site
https://doi.org/10.1242/dmm.052559- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-11-03 09:22:07
Last Modified: 2025-11-03 09:23:54