Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis

Edler, P; Rajasekhar, M; Price, DJ; Adam, I; Awab, GR; Barber, BE; Brasil, LW; Chamma-Siqueira, NN; Chu, CS; Cui, L; Daher, A; Gomes, Mdsm; Gonzalez-Ceron, L; Grigg, MJ; Karunajeewa, H; Lacerda, MVG; Ladeia-Andrade, S; Leslie, T; Ley, B; Lidia, K; Llanos-Cuentas, A; Longley, RJ; Manning, L; Mekonnen, DA; Monteiro, WM; Moore, BR; Nosten, F; Pasaribu, AP; Pereira, DB; Poespoprodjo, JR; Pukrittayakamee, S; Rijal, KR; Saravu, K; Siqueira, AM; Sutanto, I; Taylor, WRJ; Thanh, PV; Thriemer, K; Vieira, JLF; White, NJ; Yeshiwondim, AK; Zuluaga-Idarraga, LM; Guerin, PJ; Simpson, JA; Price, RN; Commons, RJ

Author(s): Edler, P; Rajasekhar, M; Price, DJ; Adam, I; Awab, GR; Barber, BE; Brasil, LW; Chamma-Siqueira, NN; Chu, CS; Cui, L; Daher, A; Gomes, Mdsm; Gonzalez-Ceron, L; Grigg, MJ; Karunajeewa, H; Lacerda, MVG; Ladeia-Andrade, S; Leslie, T; Ley, B; Lidia, K; Llanos-Cuentas, A; Longley, RJ; Manning, L; Mekonnen, DA; Monteiro, WM; Moore, BR; Nosten, F; Pasaribu, AP; Pereira, DB; Poespoprodjo, JR; Pukrittayakamee, S; Rijal, KR; Saravu, K; Siqueira, AM; Sutanto, I; Taylor, WRJ; Thanh, PV; Thriemer, K; Vieira, JLF; White, NJ; Yeshiwondim, AK; Zuluaga-Idarraga, LM; Guerin, PJ; Simpson, JA; Price, RN; Commons, RJ;
Details: Publication Year 2025-11-14,Volume 24,Issue #1,Page 400
Journal Title: Malaria Journal
Abstract: BACKGROUND: The antirelapse efficacy of primaquine is related to the total dose administered, whereas the risks of haemolysis and gastrointestinal intolerance are associated with the daily dose administered. National Malaria Control Programmes require local information on efficacy, tolerability and safety to optimize antimalarial treatment policies for Plasmodium vivax malaria control and elimination efforts. METHODS: A living systematic review identified efficacy studies of uncomplicated P. vivax malaria including patients treated with daily primaquine regimens, published since January 1, 2000. Available data were pooled and an R Shiny app was developed to integrate statistical analyses performed using R and Stata that assessed the impact of primaquine mg/kg dose on efficacy, hematological safety and gastrointestinal tolerability. RESULTS: As of January 16, 2025, a total of 9,270 individual patient data records from 41 studies have been collated into the standardized repository. Open-access automated reports were generated for user-selected countries or regions to investigate location specific effects of primaquine dose on efficacy, safety and tolerability. The reports include visual and tabular displays of the outcomes. CONCLUSIONS: These automated reports leverage a large database to provide accessible data for national and regional policy makers and researchers to assess the clinical consequences of different primaquine regimens in different endemic settings. The reports will inform local and regional policy decisions and research priorities in vivax-endemic areas.
Publisher: BMC
Keywords: *Primaquine/adverse effects/administration & dosage/therapeutic use; *Antimalarials/adverse effects/administration & dosage/therapeutic use; *Malaria, Vivax/drug therapy; Humans; Plasmodium vivax/drug effects; Treatment Outcome; Plasmodium vivax; Automated report; Dose; Efficacy; Haemolysis; Malaria; Primaquine; Recurrence; Relapse; Tolerability
Research Division(s): Infection and Global Health
Publisher's Version: https://doi.org/10.1186/s12936-025-05642-w
Open Access at Publisher's Site: https://doi.org/10.1186/s12936-025-05642-w
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2025-12-02 09:39:29

Last Modified: 2025-12-02 09:40:42