Flicking the switch for B-cell development
- Details
- Publication Year 2026-02-02,Volume 40,Issue #3-4,Page 143-145
- Journal Title
- Genes & Development
- Abstract
- The production of B cells is essential for a functional immune system. This process relies on the coordinated activity of a handful of transcription factors that act in part by modifying the chromatin landscape of lymphoid progenitors to allow the ordered expression of genes essential for B-cell development. In this issue of Genes & Development, Tingvall-Gustafsson and colleagues (doi:10.1101/gad.353002.125) have investigated the interplay of these transcriptional regulators with the chromatin state of developing lymphocytes at single-cell resolution. They pinpoint a rare population of progenitors where this epigenetic reprogramming occurs to simultaneously repress the expression of lineage-inappropriate genes and activate the B-cell program.
- Publisher
- CSH Press
- Keywords
- *B-Lymphocytes/cytology; Animals; Chromatin/metabolism; Transcription Factors/metabolism; Epigenesis, Genetic; *Cell Differentiation/genetics; Humans; Cell Lineage/genetics; B-lymphocytes; epigenetics; transcription
- Research Division(s)
- Immunology
- PubMed ID
- 41298080
- Publisher's Version
- https://doi.org/10.1101/gad.353397.125
- Open Access at Publisher's Site
https://doi.org/10.1101/gad.353397.125- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2025-12-02 09:39:29
Last Modified: 2026-02-09 09:24:35