Age-associated defect in ADCC response to COVID-19 vaccine
- Author(s)
- Sievers, BL; Altaf, M; Cheng, MTK; Kamelian, K; Cormie, C; Doffinger, R; Gupta, RK; CITIID-NIHR BioResource COVID-19 Collaboration; includes Smith, KGC;
- Details
- Publication Year 2025-07-01,Volume 10,Issue #1,Page 132
- Journal Title
- NPJ Vaccines
- Abstract
- We investigated age-associated effects of SARS-CoV-2 vaccination in elderly individuals (n = 50, mean age 79) after six SARS-CoV-2 vaccine doses. While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. These findings highlight age-related impairments in Fc-mediated responses, with implications for immune protection and vaccine strategies in older populations.
- Publisher
- Springer Nature
- PubMed ID
- 40593808
- Publisher's Version
- https://doi.org/10.1038/s41541-025-01196-9
- Open Access at Publisher's Site
https://doi.org/10.1038/s41541-025-01196-9- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-01-22 10:03:38
Last Modified: 2026-01-22 10:03:53