A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria

Opi, DH; Longley, RJ; Takashima, E; Spelman, T; Tayipto, Y; Schoffer, K; Brewster, J; Reiling, L; Wines, BD; Kiniboro, B; Siba, P; Harbers, M; HOGARTH, M; Tsuboi, T; Robinson, LJ; Mueller, I; Beeson, JG

Author(s): Opi, DH; Longley, RJ; Takashima, E; Spelman, T; Tayipto, Y; Schoffer, K; Brewster, J; Reiling, L; Wines, BD; Kiniboro, B; Siba, P; Harbers, M; HOGARTH, M; Tsuboi, T; Robinson, LJ; Mueller, I; Beeson, JG;
Details: Publication Year 2026-03-10,Volume 59,Issue #3,Page 783-797 e4
Journal Title: Immunity
Abstract: Plasmodium vivax is the most widespread cause of malaria with a high burden of disease. Progress in reducing the global malaria burden has stalled with no vaccines available partly due to a limited knowledge of targets and mechanisms of protective immunity. We developed a platform to quantify antibody functions to multiple P. vivax antigens and dissect immunity in a longitudinal cohort of children from Papua New Guinea at risk of P. vivax malaria. We identified antigens targeted by multiple functional antibodies, including interactions with Fcgamma receptors, which mediate different cellular effector functions, and complement fixation, advancing our understanding of P. vivax immunity. We identified specific antigens targeted by antibodies associated with protection from P. vivax malaria. Evaluating thousands of possible combinations, we identified subsets of antigens in the most protective combinations providing leads for developing highly protective multi-antigen P. vivax vaccines eliciting multi-functional antibody responses to achieve and sustain elimination.
Publisher: Cell Press
Keywords: Humans; *Malaria, Vivax/immunology/parasitology; *Plasmodium vivax/immunology; Longitudinal Studies; *Antibodies, Protozoan/immunology; Child; *Antigens, Protozoan/immunology; Papua New Guinea; Child, Preschool; Female; Malaria Vaccines/immunology; *Immunoglobulin Fc Fragments/immunology; Male; Receptors, IgG/immunology/metabolism; Fcgamma receptor binding; Plasmodium vivax malaria; antibodies; children; complement-fixation; malaria vaccines
Research Division(s): Infection and Global Health
PubMed ID: 41759513
Publisher's Version: https://doi.org/10.1016/j.immuni.2026.02.003
Open Access at Publisher's Site: https://doi.org/10.1016/j.immuni.2026.02.003.
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2026-03-16 01:38:21

Last Modified: 2026-03-16 01:52:35