Blood proteomics: insights from public data
- Author(s)
- Larrea-Sebal, A; Dai, C; Brenes, AJ; Korff, K; Neely, BA; Geyer, PE; Dagley, LF; Unwin, RD; Naba, A; MacCoss, MJ; Guo, T; Deutsch, EW; Martin, C; Schwenk, JM; Perez-Riverol, Y;
- Journal Title
- Genome Biology
- Abstract
- The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics have improved sensitivity and throughput, enabling the generation of public blood proteomics resources. However, comprehensive assessments of these datasets remain limited. This work reviews the cellular and molecular complexity of publicly available blood proteomics data, recent methodological developments, and the complementarity of diverse data sources across the abundance range, while outlining remaining challenges for translating blood proteomics into personalized medicine.
- Publisher
- Springer Nature
- Keywords
- *Proteomics/methods; Humans; *Proteome; *Blood Proteins/analysis; Mass Spectrometry; Precision Medicine
- Research Division(s)
- Advanced Technology and Biology
- PubMed ID
- 41821120
- Publisher's Version
- https://doi.org/10.1186/s13059-026-04027-9
- Open Access at Publisher's Site
https://doi.org/10.1186/s13059-026-04027-9 - Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-03-16 01:38:28
Last Modified: 2026-03-16 01:52:35