The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development
- Author(s)
- Fulford, TS; Koay, HF; Grumont, R; Johnson, DN; Scheer, S; Nel, HJ; Thomas, R; Mak, JY; Fairlie, DP; Teh, CE; Gray, DH; Bryant, VL; Zaph, C; O'Reilly, LA; Gerondakis, S; Godfrey, DI;
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Feb 23
- Abstract
- Mucosal-associated invariant T (MAIT) cells are characterized by rapid responses to nonpeptide antigens via invariant T-cell receptors (TCR), and expression of an "effector-like" T-cell phenotype. The transcription factor promyelocytic leukemia zinc finger (PLZF) is crucial for defining the function of MAIT cells and other unconventional T cells; however, the transcriptional programs that direct MAIT cell development are not fully elucidated. Here, we show that the canonical NF-κB transcription factor RelA is critical for MAIT cell thymic development, but not responsiveness to antigen, whereas NF-κB1 and c-Rel make more limited contributions. MAIT cell development is also impaired in the absence of the linear ubiquitin signaling complex (LUBAC), an upstream regulator of NF-κB signaling, implicating this pathway in establishing the MAIT cell pool. Collectively, these data suggest LUBAC and NF-κB signals as elements of the transcriptional network controlling MAIT cell development.
- Publisher
- Wiley
- Keywords
- Lubac; MAIT cells; Nf‐κb; RelA; development
- Research Division(s)
- Immunology; Infection and Global Health
- PubMed ID
- 41732015
- Publisher's Version
- https://doi.org/10.1111/imcb.70096
- Open Access at Publisher's Site
https://doi.org/10.1111/imcb.70096- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2026-03-16 01:38:29
Last Modified: 2026-03-16 01:52:35