SIRT2 antagonizes MOF function during mitotic entry

Espinosa-Alcantud, M; Sima, N; Fern&#225;ndez-Duran, I; Marazuela-Duque, A; Mart&#237;nez-Cebri&#225;n, G; Guitart-Solanes, A; G&#225;mez-Garc&#237;a, A; Mart&#237;nez-Redondo, P; Bosch-Presegu&#233;, L; Vazquez, BN; Pa&#241;os, L; Bech, JJ; Thomas, T; Martinez-Balb&#225;s, MA; Voss, AK; Kr&#252;ger, M; Serrano, L; Olivella, M; Cuartero, S; de la Torre, C; Vaquero, A

Author(s): Espinosa-Alcantud, M; Sima, N; Fernández-Duran, I; Marazuela-Duque, A; Martínez-Cebrián, G; Guitart-Solanes, A; Gámez-García, A; Martínez-Redondo, P; Bosch-Presegué, L; Vazquez, BN; Paños, L; Bech, JJ; Thomas, T; Martinez-Balbás, MA; Voss, AK; Krüger, M; Serrano, L; Olivella, M; Cuartero, S; de la Torre, C; Vaquero, A;
Details: Publication Year 2026-06-19,Volume 12,Issue #25,Page eaeb2915
Journal Title: Science Advances
Abstract: Mitosis entry is tightly regulated by a complex network of mechanisms involving epigenetic modifications, signaling pathways, transcriptional control, and structural changes. Although substantial progress has been made in understanding these processes individually, the mechanisms integrating chromatin dynamics with mitotic regulators are still not fully understood. Here, we identify a functional antagonism between the deacetylase SIRT2 and the acetyltransferase MOF in the G(2)-M transition and mitotic progression. This interplay, which involves MOF deacetylation by SIRT2, regulates key histone marks, including H4K16ac (histone 4 lysine-16 acetylation) deacetylation and H4K20me1 (histone 4 lysine-20 monomethylation) deposition, condensin II loading, and the stability of the key mitotic regulator PLK1, and contributes to the FOXM1-mediated transcriptional control of mitosis. Our findings reveal a previously unrecognized layer of regulation in G(2)-M progression with possible impact in cancer, highlighting the intricate cross-talk between chromatin dynamics and mitotic control and providing important insights into chromosomal stability.
Publisher: AAAS
Keywords: *Mitosis/genetics; *Sirtuin 2/metabolism/genetics; Humans; Acetylation; Histones/metabolism; *Histone Acetyltransferases/metabolism/genetics/antagonists & inhibitors; Protein Serine-Threonine Kinases/metabolism/genetics; Cell Cycle Proteins/metabolism/genetics; Forkhead Box Protein M1/metabolism/genetics; Proto-Oncogene Proteins/metabolism/genetics; Polo-Like Kinase 1; DNA-Binding Proteins/metabolism; Multiprotein Complexes/metabolism; Chromatin/metabolism; Adenosine Triphosphatases
Research Division(s): Genetics and Gene Regulation
PubMed ID: 42319919
Publisher's Version: https://doi.org/10.1126/sciadv.aeb2915
Open Access at Publisher's Site: https://doi.org/10.1126/sciadv.aeb2915
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2026-06-26 08:17:24

Last Modified: 2026-06-26 08:20:37