Self-efficacy in idiopathic inflammatory myopathies: associated factors, profiles and patient-reported outcomes

Yaadav, P; Minikumari Rahulan, L; Hussain, S; SARKAR, M; Venerito, V; Maroufy, V; Pellico, MR; Russell, AM; Saha, S; Nikiphorou, E; Parodis, I; Limaye, VS; da Silva, DLF; Shinjo, SK; Day, J; Levy, AL; Cheng, K; Andreoli, L; Parihar, J; Agarwal, V; Gupta, L

Author(s): Yaadav, P; Minikumari Rahulan, L; Hussain, S; SARKAR, M; Venerito, V; Maroufy, V; Pellico, MR; Russell, AM; Saha, S; Nikiphorou, E; Parodis, I; Limaye, VS; da Silva, DLF; Shinjo, SK; Day, J; Levy, AL; Cheng, K; Andreoli, L; Parihar, J; Agarwal, V; Gupta, L;
Details: Publication Year 2026-09-01,Volume 65,Issue #9,Page keag458
Journal Title: Rheumatology
Abstract: OBJECTIVES: Self-efficacy (SE) is central to chronic disease self-management but remains poorly characterized in idiopathic inflammatory myopathies (IIMs). We aimed to identify factors associated with SE, characterize SE profiles and examine associations with patient-reported outcomes (PROs) in IIMs. METHODS: Cross-sectional data from 5802 participants across IIMs, other rheumatic diseases (RMDs) and non-rheumatic autoimmune diseases (nRAIDs) were analysed. SE was measured using the Self-Efficacy for Managing Chronic Disease (SEMCD) scale. Hierarchical regression identified factors independently associated with SE, and k-means clustering defined SE health profiles. Associations with PROs were examined in a separate multivariable model. RESULTS: IIM patients had lower SE (median SEMCD 5.3) than those with RMDs (5.8) and nRAIDs (6.5), with confidence lowest for managing fatigue and physical discomfort. In the fully adjusted integrated model (R² = 0.222), mental health comorbidity (B = -0.898) and financial difficulty (B = -0.734) were most strongly associated with lower SE, while regular exercise (B = 0.770) and family support (B = 0.150) were associated with higher SE. The PRO model explained 48.3% of SE variance (R² = 0.483); resilience was the strongest positive association, while fatigue and pain were negatively associated. Four SE health profiles were identified, including a clinically distinctive resilient-despite-burden subgroup (24%) with high symptom burden but preserved SE and mental health. Higher SE was associated with better physical and mental health, greater resilience and life satisfaction, and lower fatigue, pain and loneliness (all P < 0.001). CONCLUSION: SE in IIMs is associated with modifiable socioeconomic and psychological factors and with better health outcomes. Profile-based stratification may help identify vulnerable subgroups and guide targeted interventions.
Keywords: Humans; Female; *Myositis/psychology/therapy; *Patient Reported Outcome Measures; Male; Cross-Sectional Studies; *Self Efficacy; Middle Aged; Adult; Aged; Quality of Life; Fatigue/psychology; Self Care/psychology; Rheumatic Diseases/psychology; cluster analysis; idiopathic inflammatory myopathies; mental health comorbidity; myositis; patient-reported outcomes; self-efficacy; self-management
Research Division(s): Inflammation
PubMed ID: 42640566
Publisher's Version: https://doi.org/10.1093/rheumatology/keag458
Open Access at Publisher's Site: https://doi.org/10.1093/rheumatology/keag458
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2026-10-02 08:19:00

Last Modified: 2026-10-02 08:19:08