Suppression or overexpression of genes encoding myeloid growth factors or their receptors
- Author(s)
- Metcalf, D;
- Details
- Publication Year 1997-04,Volume 39,Issue #2,Page 98-101
- Journal Title
- HEMATOLOGY AND CELL THERAPY
- Publication Type
- Journal Article
- Abstract
- Gene inactivation data have documented that erythropoietin, G-CSF, M-CSF and thrombopoietin are major regulators in vivo respectively of red cell, neutrophil, macrophage and platelet production. Transgenic mice can provide valuable models for observing the consequences of excessive stimulation by a particular growth factor but are subject to variation based on the use of differing promoters for the inserted gene.
- Publisher
- SPRINGER VERLAG
- Keywords
- COLONY-STIMULATING FACTOR; MYELOPROLIFERATIVE SYNDROME; DEFICIENT MICE; FATAL SYNDROME; TISSUE-DAMAGE; MACROPHAGE; GRANULOCYTE; CELLS; ERYTHROPOIETIN; OSTEOPETROSIS
- Publisher's Version
- https://doi.org/10.1007/s00282-997-0098-0
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-04-01 12:00:00