Suppression or overexpression of genes encoding myeloid growth factors or their receptors
Author(s)
Metcalf, D;
Details
Publication Year 1997-04,Volume 39,Issue #2,Page 98-101
Journal Title
HEMATOLOGY AND CELL THERAPY
Publication Type
Journal Article
Abstract
Gene inactivation data have documented that erythropoietin, G-CSF, M-CSF and thrombopoietin are major regulators in vivo respectively of red cell, neutrophil, macrophage and platelet production. Transgenic mice can provide valuable models for observing the consequences of excessive stimulation by a particular growth factor but are subject to variation based on the use of differing promoters for the inserted gene.
Publisher
SPRINGER VERLAG
Keywords
COLONY-STIMULATING FACTOR; MYELOPROLIFERATIVE SYNDROME; DEFICIENT MICE; FATAL SYNDROME; TISSUE-DAMAGE; MACROPHAGE; GRANULOCYTE; CELLS; ERYTHROPOIETIN; OSTEOPETROSIS
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 1997-04-01 12:00:00
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