Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
- Author(s)
- Irmler, M; Hofmann, K; Vaux, D; Tschopp, J;
- Details
- Publication Year 1997-04-07,Volume 406,Issue #1-2,Page 189-190
- Journal Title
- FEBS LETTERS
- Publication Type
- Journal Article
- Abstract
- The two genes CED-4 and CED-3 (the nematode homologue of interleukin-1 beta converting enzyme, ICE) of Caenorhabditis elegans are implicated in the control of cell death, but the mechanism by which this occurs is unknown, Here we provide evidence that CED-3 and CED-3 both contain sequences with homology to a domain present in RAIDD and the prodomain of certain ICE-like proteases (caspases). This domain is known to establish an interaction between RAIDD and these caspases. Similarly, CED-4 was found to interact with CED-3. Thus, the activity of the death protease CED-3 appears to be controlled by CED-4 through a direct physical interaction. (C) 1997 Federation of European Biochemical Societies.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- CELL-DEATH; ENCODES
- Publisher's Version
- https://doi.org/10.1016/S0014-5793(97)00271-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-04-07 12:00:00