Monozygotic twins discordant for congenital complete heart block
- Author(s)
- Cooley, HM; Keech, CL; Melny, BJ; Menahem, S; Morahan, G; Kay, TWH;
- Details
- Publication Year 1997-02,Volume 40,Issue #2,Page 381-384
- Journal Title
- ARTHRITIS AND RHEUMATISM
- Publication Type
- Journal Article
- Abstract
- Objective. Isolated congenital complete heart block (CCHB) occurs in 1/20,000 live births. More than 85% of mothers giving birth to affected infants are anti-Ro antibody positive, but only similar to 1% of babies with anti-Ro-positive mothers develop CCHB. We studied 2 sets of monozygotic twins discordant for CCHB. Methods. Monozygosity was deter;mined using placental examination and DNA microsatellite analysis. HLA typing was performed, Autoantibody studies were performed using counterimmunoelectrophoresis, immunoblotting, Ro 52 and Ro 60 enzyme-linked immunosorbent assay (ELISA), and indirect immuno-fluorescence (IIF) on Ro 60- and Ro 52-transfected HEp-2 cells. Results. Both sets of twins were monozygotic. They had similar birth weights. Twin 2 in the second set required a pacemaker at age 2 months, Both mothers were positive for anti-Po 52 and anti-Re 60 antibody, and neither had anti-La antibody on immunoblot, One set of twins was studied at birth, Similar titers of anti-Re 52 and anti-Re 60 antibody were found by IIF and ELISA. Conclusion. There are no previous well-documented reports of monozygotic twins discordant for CCHB, These cases demonstrate that there is still discordance in the development of CCHB despite identical genetics and environmental exposure to anti-Ro antibody.
- Publisher
- LIPPINCOTT-RAVEN PUBL
- Keywords
- NEONATAL LUPUS-ERYTHEMATOSUS; CONNECTIVE-TISSUE DISEASE; RO/SS-A; ANTIBODIES; AUTOANTIBODIES; AUTOANTIGEN; FETAL
- Publisher's Version
- https://doi.org/10.1002/art.1780400223
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-02-01 12:00:00