A putative Plasmodium falciparum exported serine/threonine protein kinase

Author(s): Kun, JFJ; Hibbs, AR; Saul, A; McColl, DJ; Coppel, RL; Anders, RF;
Details: Publication Year 1997-03,Volume 85,Issue #1,Page 41-51
Journal Title: MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Publication Type: Journal Article
Abstract: An 8kb gene coding for a putative serine/threonine protein kinase from Plasmodium falciparum has been cloned and sequenced. It is arranged in two exons: exon I is 2 kb and exon II is 5.6 kb. The gene codes for a large protein of 2510 amino acids. Antibodies raised against a fusion protein were used to localize the putative kinase. By immunofluorescence microscopy, it was found in the cytoplasm of infected red cells. By immunoelectron microscopy it was associated with membranous structures in the red cell and with the red cell membrane, particularly at parasite-induced knobs. This is the first putative protein kinase of P. falciparium to be exported from the parasite into its host cell. (C) 1997 Elsevier Science B.V.
Publisher: ELSEVIER SCIENCE BV
Keywords: HOST-CELL MEMBRANE; ERYTHROCYTE-MEMBRANE; INFECTED ERYTHROCYTES; RICH PROTEIN; BLOOD-STAGE; PHOSPHORYLATION; PARASITE; EXPRESSION; MALARIA; GENE
Publisher's Version: https://doi.org/10.1016/S0166-6851(96)02805-8
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1997-03-01 12:00:00