Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression
- Author(s)
- Robb, L; Hilton, DJ; BrookCarter, PT; Begley, CG;
- Details
- Publication Year 1997-03-15,Volume 40,Issue #3,Page 387-394
- Journal Title
- GENOMICS
- Publication Type
- Journal Article
- Abstract
- The interleukin-ll receptor alpha-chain, a member of the hematopoietin receptor superfamily, forms, together with gp130, a functional high-affinity receptor complex for interleukin 11. We, and others, reported the cloning of the murine interleukin 11 receptor alpha-chain cDNA (IL11Ra) and recently described the structure of the IL11Ra locus. We also described the presence of a second IL11Ra-like locus in some mouse strains. In this study we report that the second locus, designated IL11Ra2, encodes an mRNA species. The transcript was 99% identical to the IL11Ra transcript in the coding and 3'-untranslated region, but had a different 5'-untranslated region. The complete genomic organization of the IL11Ra2 locus is presented, and the two loci are shown to be located on a 200-kb NaeI genomic fragment. Comparison of the expression pattern of the IL11Ra and IL11Ra2 genes using an RT-PCR restriction fragment length polymorphism strategy revealed that while the expression of IL11Ra was widespread, expression of IL11Ra2 was restricted to testis, lymph node, and thymus. (C) 1997 Academic Press.
- Publisher
- ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
- Keywords
- COLONY-STIMULATING FACTOR; MOLECULAR-CLONING; HEMATOPOIETIC CYTOKINE; INHIBITORY FACTOR; PROGENITOR CELLS; FAMILY; SUPERFAMILY; EVOLUTION; INVITRO; GP130
- Publisher's Version
- https://doi.org/10.1006/geno.1996.4579
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-03-15 12:00:00