Integration of hepatitis B vaccination into the expanded programme on immunization in Chonburi and Chiangmai provinces, Thailand

Author(s): Chunsuttiwat, S; Biggs, BA; Maynard, J; Thamapalo, S; Laoboripat, S; Bovornsin, S; Charanasri, U; Pinyowiwat, W; Kunasol, P;
Details: Publication Year 1997-04,Volume 15,Issue #6-7,Page 769-774
Journal Title: VACCINE
Publication Type: Journal Article
Abstract: Hepatitis B (HB) immunization was introduced as part of the expanded programme on immunization (EPI) in two provinces in Thailand and evaluated over a four year period. Three doses of HB vaccine were offered to 60980 newborns at birth, 2 and 6 months of age. The overall coverage for complete HB immunization was 90.4%. Serosurveys of randomly selected children under the age of 5 years were undertaken before and at the end of the project. Levels of HBsAg positivity were reduced by 85%, and there was a corresponding 70% increase in protective immunity. These findings demonstrate that HB immunization can be successfully integrated into EPI without adverse effect on coverage rates of other antigens, and results in a marked reduction in the rate of chronic carriage of HB virus in preschool age children. (C) 1997 Elsevier Science Ltd.
Publisher: ELSEVIER SCI LTD
Keywords: HEPATOCELLULAR-CARCINOMA; VIRUS-INFECTION; PREVENTION; IMMUNOGENICITY; EFFICACY; MODEL; MEN
Publisher's Version: https://doi.org/10.1016/S0264-410X(96)00226-5
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1997-04-01 12:00:00