Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHz electromagnetic fields
- Author(s)
- Repacholi, MH; Basten, A; Gebski, V; Noonan, D; Finnie, J; Harris, AW;
- Details
- Publication Year 1997-05,Volume 147,Issue #5,Page 631-640
- Journal Title
- RADIATION RESEARCH
- Publication Type
- Journal Article
- Abstract
- Whether radiofrequency (RF) fields are carcinogenic is controversial; epidemiological data have been inconclusive and animal tests limited. The aim of the present study was to determine whether long-term exposure to pulse-modulated RF fields similar to those used in digital mobile telecommunications would increase the incidence of lymphoma in E mu-Pim1 transgenic mice, which are moderately predisposed to develop lymphoma spontaneously. One hundred female E mu-Pim1 mice were sham-exposed and 101 were exposed for two 30-min periods per day for up to 18 months to plane-wave fields of 900 MHz with a pulse repetition frequency of 217 Hz and a pulse width of 0.6 ms. Incident power densities were 2.6-13 W/m(2) and specific absorption rates were 0.008-4.2 W/kg, averaging 0.13-1.4 W/kg. Lymphoma risk was found to be significantly higher in the exposed mice than in the controls (OR = 2.4, P = 0.006, 95% CI = 1.3-4.5). Follicular lymphomas were the major contributor to the increased tumor incidence. Thus long-term intermittent exposure to RF fields can enhance the probability that mice carrying a lymphomagenic oncogene will develop lymphomas. We suggest that such genetically cancer-prone mice provide an experimental system for more detailed assessment of dose-response relationships for risk of cancer after RF-field exposure. (C) 1997 by Radiation Research Society.
- Publisher
- RADIATION RESEARCH SOC
- Keywords
- RADIO-FREQUENCY RADIATION; MICROWAVE-RADIATION; TUMOR-DEVELOPMENT; AQUEOUS-SOLUTIONS; CANCER; DNA; CARCINOGEN; ABSORPTION; MOUSE; HEAD
- Publisher's Version
- https://doi.org/10.2307/3579630
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-05-01 12:00:00