LIF potentiates the NT-3-mediated survival of spiral ganglia neurones in vitro
- Author(s)
- Marzella, PL; Clark, GM; Shepherd, RK; Bartlett, PF; Kilpatrick, TJ;
- Details
- Publication Year 1997-05-06,Volume 8,Issue #7,Page 1641-1644
- Journal Title
- NEUROREPORT
- Publication Type
- Journal Article
- Abstract
- THE survival of auditory neurones depends on the continued supply of trophic factors. Early postnatal spiral ganglion cells (SGC) in a dissociated cell culture were used as a model of auditory innervation to test the trophic factors leukaemia inhibitory factor (LIF) and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings suggest that LIF supports neuronal survival in a concentration-dependent manner. Moreover LIF potentiated NT-3-mediated spiral ganglion neuronal survival in a synergistic fashion.
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- LEUKEMIA INHIBITORY FACTOR; NERVE
- Publisher's Version
- https://doi.org/10.1097/00001756-199705060-00017
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-05-06 12:00:00