The age-specific prevalence of Plasmodium falciparum in migrants to Irian Jaya is not attributable to agglutinating antibody repertoire
- Author(s)
- Reeder, JC; Davern, KM; Baird, JK; Rogerson, SJ; Brown, GV;
- Details
- Publication Year 1997-05-30,Volume 65,Issue #3,Page 163-173
- Journal Title
- ACTA TROPICA
- Publication Type
- Journal Article
- Abstract
- Previous observations have shown that individuals migrating from a malaria free area to a malaria endemic region in North Eastern Irian Jaya quickly acquire anti-parasite immunity, in an age-dependent manner. Sera from migrants and long-term residents in this area were examined for their ability to agglutinate a range of Plasmodium falciparum isolates and to disrupt erythrocyte rosettes. Antibody responses to merozoite surface protein 2 (MSP2) and ring-infected erythrocyte surface antigen (RESA) were also determined. The range of isolates agglutinated by sera from the migrants approached that seen in long-term residents. No difference was found between migrant adults and children in the range of agglutinating antibody, size of agglutinates, nor disruption of rosettes. Anti-MSP2 and anti-RESA antibodies were the only factors examined which showed a correlation with age. We conclude that although antibody to parasite neoantigens expressed on the surface of infected erythrocytes may play a role in the acquisition of immunity, the humoral response to other P. falciparum antigens is more likely to account for the age-dependent prevalence of parasitaemia observed. (C) 1997 Elsevier Science B.V.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- PAPUA-NEW-GUINEA; ERYTHROCYTE SURFACE-ANTIGEN; HUMAN CEREBRAL MALARIA; HIGHLY ENDEMIC AREA; INFECTED ERYTHROCYTES; HUMORAL RESPONSE; PROTECTION; DIVERSITY; CYTOADHERENCE; TRANSMISSION
- Publisher's Version
- https://doi.org/10.1016/S0001-706X(97)00661-X
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-05-30 12:00:00