B cell memory in xid mice is long-lived despite reduced memory B cell frequency
- Author(s)
- Ridderstad, A; Tarlinton, DM;
- Details
- Publication Year 1997-06,Volume 45,Issue #6,Page 655-659
- Journal Title
- SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Brutons tyrosine kinase (Btk) deficient rid mice have a diminished primary T cell dependent immune response, resulting in a reduced memory B cell frequency. Boosting at 35 days post primary immunization, however, generates a normal secondary immune response, indicating a functional memory B cell compartment. The longevity of B cell memory appears to depend on both the presence of antigen and expression of cell survival genes such as bcl-2. Since there is a natural decay in the number of memory B cells over time and since rid B cells have been demonstrated to have reduced Bcl-2 levels, we aimed at determining whether B cell memory of rid mice would be long-lasting. This report demonstrates that memory B cell precursors are detectable in rid mice more than 100 days after primary immunization. Furthermore, a secondary immune response of normal magnitude and kinetics can be generated in rid mice at 150 days after primary immunization indicating that B cell memory is long-lived in rid mice. Thus, although survival of B cell memory is presumably dependent on immunoglobulin (Ig)-mediated interaction with antigen, this interaction does not depend solely on signalling through Btk.
- Publisher
- BLACKWELL SCIENCE LTD
- Keywords
- X-LINKED IMMUNODEFICIENCY; BRUTON TYROSINE KINASE; AFFINITY MATURATION; IMMUNE-RESPONSE; BONE-MARROW; ANTIGEN; SELECTION
- Publisher's Version
- https://doi.org/10.1046/j.1365-3083.1997.d01-444.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-06-01 12:00:00