Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area
Publication Year 1997-06, Volume 19, Issue #6, Page 249-254
- Journal Title
- PARASITE IMMUNOLOGY
- Publication Type
- Journal Article
- A prospective study in 207 children aged 0.5-15 years was carried out to examine the relationship between cellular responses to Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA) and malaria infection and morbidity. The prevalence of lymphoproliferative response to RESA was 13%, IFN-gamma prevalence was 40% and IL-4 prevalence was 22%. Only the IFN-gamma, response to RESA increased significantly with age. When proliferation or stimulation of either cytokine was used to assess T-cell activation the overall frequency of responders increased to 55%. The proliferative and IFN-gamma response to RESA were positively associated. Although there was no association between any of the CMI responses to RESA and concurrent morbidity the prevalence of IL-4 response to RESA was significantly lower in children who experienced clinical malaria in the following year. These results coupled with our earlier darn showing a negative relationship between humoral responses to RESA and malaria morbidity support the inclusion of RESA in a subunit vaccine against malaria.
- BLACKWELL SCIENCE LTD
- ERYTHROCYTE SURFACE-ANTIGEN; EAST SEPIK PROVINCE; PLASMODIUM-FALCIPARUM; HUMORAL RESPONSE; PF155 RESA; CIRCUMSPOROZOITE PROTEIN; IMMUNE RECOGNITION; VACCINE TRIALS; WOSERA AREA; ANTIBODIES
- Publisher's Version
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Creation Date: 1997-06-01 12:00:00Last Modified: 0001-01-01 12:00:00