Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area
- Author(s)
- AlYaman, F; Genton, B; Taraika, J; Anders, R; Alpers, MP;
- Details
- Publication Year 1997-06,Volume 19,Issue #6,Page 249-254
- Journal Title
- PARASITE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- A prospective study in 207 children aged 0.5-15 years was carried out to examine the relationship between cellular responses to Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA) and malaria infection and morbidity. The prevalence of lymphoproliferative response to RESA was 13%, IFN-gamma prevalence was 40% and IL-4 prevalence was 22%. Only the IFN-gamma, response to RESA increased significantly with age. When proliferation or stimulation of either cytokine was used to assess T-cell activation the overall frequency of responders increased to 55%. The proliferative and IFN-gamma response to RESA were positively associated. Although there was no association between any of the CMI responses to RESA and concurrent morbidity the prevalence of IL-4 response to RESA was significantly lower in children who experienced clinical malaria in the following year. These results coupled with our earlier darn showing a negative relationship between humoral responses to RESA and malaria morbidity support the inclusion of RESA in a subunit vaccine against malaria.
- Publisher
- BLACKWELL SCIENCE LTD
- Keywords
- ERYTHROCYTE SURFACE-ANTIGEN; EAST SEPIK PROVINCE; PLASMODIUM-FALCIPARUM; HUMORAL RESPONSE; PF155 RESA; CIRCUMSPOROZOITE PROTEIN; IMMUNE RECOGNITION; VACCINE TRIALS; WOSERA AREA; ANTIBODIES
- Publisher's Version
- https://doi.org/10.1046/j.1365-3024.1997.d01-204.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-06-01 12:00:00