Antigenic variation and immune evasion in Plasmodium falciparum malaria
- Author(s)
- Reeder, JC; Brown, GV;
- Details
- Publication Year 1996-12,Volume 74,Issue #6,Page 546-554
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Plasmodium falciparum malaria is responsible for 2 million deaths each year. Even in endemic regions, immunity to malaria builds slowly and is rarely complete. Strategies such as antigenic variation and antigenic diversity are critical to a parasite's ability to evade the host immune response and infect previously exposed individuals. In this short review, the phenomenon of antigenic variation is discussed in relation to immune evasion and its impact on parasite pathogenesis. Recent advances in the understanding of the underlying molecular mechanisms of antigenic variation are examined and questions posed for future research.
- Publisher
- BLACKWELL SCIENCE
- Keywords
- HUMAN CEREBRAL MALARIA; INFECTED ERYTHROCYTES; PARASITIZED ERYTHROCYTES; ADHESION MOLECULE-1; CELL; CYTOADHERENCE; DIVERSITY; RECEPTOR; EXPRESSION; SURFACE
- Publisher's Version
- https://doi.org/10.1038/icb.1996.88
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1996-12-01 12:00:00