Mechanisms of tolerance to self

Miller, JFAP; Basten, A

Author(s): Miller, JFAP; Basten, A;
Details: Publication Year 1996-12,Volume 8,Issue #6,Page 815-821
Journal Title: CURRENT OPINION IN IMMUNOLOGY
Publication Type: Journal Article
Abstract: Several mechanisms exist to prevent lymphocytes from reacting against self-antigens. As T cells develop in the thymus and express antigen-specific receptors, those with high-affinity to self-antigens existing within the thymus are deleted. Low-affinity self-reactive T cells and T cells with receptors against antigens not represented intrathymically will mature and join the peripheral T cell pool. They may either ignore self-antigens expressed by tissues unable to activate T cells through a lack of the appropriate costimulator signals,,or they may, under certain conditions, be deleted or rendered anergic and unable to respond. Likewise, B cells that express surface Ig receptors with high binding affinity to membrane-bound self-antigens present in the bone marrow will be rescued by receptor editing or will be deleted, whereas those of lower affinity will migrate to the periphery in either an anergic or indifferent state depending on the degree of receptor engagement by antigen. Once there, their ultimate fate is determined by the availability of T cell help.
Publisher: CURRENT BIOLOGY LTD
Keywords: T-CELL-RECEPTOR; REACTIVE B-CELLS; TRANSGENIC MICE; AUTOIMMUNE-DISEASE; CLONAL DELETION; LYMPHOCYTES-B; ANTIGEN; AVIDITY; ELIMINATION; DEFICIENT
Publisher's Version: https://doi.org/10.1016/S0952-7915(96)80010-0
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1996-12-01 12:00:00