Induction of autoimmune diabetes by oral administration of autoantigen
- Author(s)
- Blanas, E; Carbone, FR; Allison, J; Miller, JFAP; Heath, WR;
- Details
- Publication Year 1996-12-06,Volume 274,Issue #5293,Page 1707-1709
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- An antigen administered orally can induce immunological tolerance to a subsequent challenge with the same antigen. Evidence has been provided for the efficacy of this approach in the treatment of human autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. However, oral administration of autoantigen in mice was found to induce a cytotoxic T lymphocyte response that could lead to the onset of autoimmune diabetes. Thus, feeding autoantigen can cause autoimmunity, which suggests that caution should be used when applying this approach to the treatment of human autoimmune diseases.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- COLLAGEN-INDUCED ARTHRITIS; MYELIN BASIC-PROTEIN; CD8(+) T-CELLS; II COLLAGEN; VIRUS-INFECTION; NOD MICE; TOLERANCE; INSULIN; SUPPRESSION; ANTIGEN
- Publisher's Version
- https://doi.org/10.1126/science.274.5293.1707
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1996-12-06 12:00:00