Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer

Basser, RL; Rasko, JEJ; Clarke, K; Cebon, J; Green, MD; Hussein, S; Alt, C; Menchaca, D; Tomita, D; Marty, J; Fox, RM; Begley, CG

Author(s): Basser, RL; Rasko, JEJ; Clarke, K; Cebon, J; Green, MD; Hussein, S; Alt, C; Menchaca, D; Tomita, D; Marty, J; Fox, RM; Begley, CG;
Details: Publication Year 1996-11-09,Volume 348,Issue #9037,Page 1279-1281
Journal Title: LANCET
Publication Type: Journal Article
Abstract: Background Pegytated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) is a potent stimulator of megakaryocyte colony formation and platelet production. It is likely to be useful in the management of severe thrombocytopenia, To determine its clinical activity and safety, we gave it to patients with advanced cancer before chemotherapy. Methods Patients were randomly assigned to receive either PEG-rHuMGDF or placebo in a three to one ratio. PEG-rHuMGDF was given at a dose of 0.03, 0.1, 0.3, or I.0 mu g/kg body weight. The study drug or placebo were administered daily by subcutaneous injection for up to 10 days or until a target platelet count was reached. Findings 17 patients, median age 59 years, received either PEG-rHuMGDF (13 patients) or placebo (four patients), PEG-rHuMGDF produced a dose-dependent increase in platelet counts. Patients given placebo, 0.03, and 0.1 mu g/kg of PEG-rHuMGDF had median increases in platelet counts of 16%, 12%, and 39%. Those receiving 0.3 and 1.0 mu g/kg of PEG-rHuMGDF had an increase in blood platelets of between 51% and 584%. Platelets rose from day 6 of PEG-rHuMGDF administration and continued to rise after stopping the drug. The platelet count peaked between days 12 and 18 and remained above 450x10(9)/L for up to 21 days. There were no alterations in white-blood-cell count or haematocrit, and low toxicity. Platelets taken from patients during PEG-rHuMGDF administration and at the time of peak platelet count were morphologically and functionally normal. Interpretation The potency with which PEG-rHuMGDF stimulates platelet production and its low toxicity indicate that this is likely to be a useful agent for the management of thrombocytopenia.
Publisher: LANCET LTD
Keywords: CARBOPLATIN-INDUCED THROMBOCYTOPENIA; C-MPL LIGAND; PLATELET PRODUCTION; OVARIAN-CANCER; INTERLEUKIN-1-ALPHA; PURIFICATION; CHEMOTHERAPY; STIMULATION; EXPRESSION; REGULATOR
Publisher's Version: https://doi.org/10.1016/S0140-6736(96)04471-6
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1996-11-09 12:00:00