Dendritic cell development: Multiple pathways to nature's adjuvants
- Author(s)
- Shortman, K; Caux, C;
- Details
- Publication Year 1997-01-01,Volume 15,Issue #6,Page 409-419
- Journal Title
- STEM CELLS
- Publication Type
- Journal Article
- Abstract
- Dendritic cells are a system of bone marrow-derived antigen-presenting cells specialized for interaction with T lymphocytes and essential for initiating primary T cell immune responses. Recent investigation indicates that dendritic cells are of diverse origin, with at least two types of myeloid precursors and a lymphoid precursor implicated in their generation. Mature dendritic cell subtypes, while sharing the capacity to activate T cells, show additional functional specialization, Some dendritic cells are equipped with additional mechanisms to regulate the response of the T cells they activate, while others are able to interact with B cells and modify B cell responses.
- Publisher
- ALPHAMED PRESS
- Keywords
- COLONY-STIMULATING FACTOR; EPIDERMAL LANGERHANS CELLS; TUMOR-NECROSIS-FACTOR; MOUSE BONE-MARROW; CD34(+) HEMATOPOIETIC PROGENITORS; ANTIGEN-PRESENTING CELL; T-CELLS; FACTOR-ALPHA; IN-VITRO; PRECURSOR CELLS
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-01-01 12:00:00