Chondroitin sulphate A as an adherence receptor for Plasmodium falciparum-infected erythrocytes

Rogerson, SJ; Brown, GV

Author(s): Rogerson, SJ; Brown, GV;
Details: Publication Year 1997-02,Volume 13,Issue #2,Page 70-75
Journal Title: PARASITOLOGY TODAY
Publication Type: Journal Article
Abstract: Until recently, the sequestration of erythrocytes infected with Plasmodium falciparum has been thought to be due to one of a number of protein-protein interactions. In this article, Stephen Rogerson and Graham Brown summarize the emerging evidence that, in vitro, infected erythrocytes can also adhere to the glycosaminoglycan chondroitin sulphate A (CSA) expressed on the surface of cells and immobilized on plastic. In vivo, binding of infected erythrocytes to CSA could be crucial to the development of material infection of the placenta, and possible to sequestration in the lung and brain. The consequences of this may include maternal morbidity and mortality, low birth weight in the infant, pulmonary oedema and cerebral malaria. They discuss the need to characterize the molecular basis of this interaction, and to investigate the possible therapeutic role of CSA in malaria. Chondroitin sulphates are nontoxic compounds already in use for other diseases in humans. Vaccines based on inhibiting this receptor-ligand interaction could be appropriate.
Publisher: ELSEVIER SCI LTD
Keywords: RECOMBINANT HUMAN THROMBOMODULIN; HEPARAN-SULFATE; MONOCLONAL-ANTIBODY; ADHESION MOLECULE-1; ANTIGENIC VARIATION; MELANOMA-CELLS; HUMAN-PLACENTA; CYTOADHERENCE; MALARIA; SURFACE
Publisher's Version: https://doi.org/10.1016/S0169-4758(96)10081-8
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1997-02-01 12:00:00