Temporal discontinuities in progression of NOD autoimmune diabetes
- Author(s)
- Rudy, GB; Sutherland, RM; Lew, AM;
- Details
- Publication Year 1997,Volume 16,Issue #2,Page 137-147
- Journal Title
- IMMUNOLOGIC RESEARCH
- Publication Type
- Journal Article
- Abstract
- Consideration of the pathophysiology of insulin-dependent diabetes mellitus in the nonobese diabetic (NOD) mouse can be viewed from a temporal perspective. We argue that there are discontinuous phases and each phase may reflect a phenotype educed by a particular set of genetic and epigenetic events. Therefore, temporal dissection may be a useful platform for causal dissection and we have set out this article as follows: 1. Introduction. 2. ''Pre-time.'' a. Genetics. b. Parental effects. 3. Development of insulitis, a. Development of autoimmunity vs waning of or failure to establish tolerance. b. Importance of beta cell mass. c. Homing. 4. Onset of beta cell destruction. 5. Further Discussion.
- Publisher
- HUMANA PRESS INC
- Keywords
- BETA-CELL DESTRUCTION; T-CELL; GENETIC-CONTROL; INSULIN AUTOANTIBODIES; MONOCLONAL-ANTIBODY; ADHESION MOLECULES; PANCREATIC-ISLETS; LYMPHOCYTES-T; CLASS-II; MICE
- Publisher's Version
- https://doi.org/10.1007/BF02786358
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-01-01 12:00:00