Stem cell antigen 2 expression in adult and developing mice

Author(s): Antica, M; Wu, L; Scollay, R;
Details: Publication Year 1997-01,Volume 55,Issue #1,Page 47-51
Journal Title: IMMUNOLOGY LETTERS
Publication Type: Journal Article
Abstract: Stem cell antigen 2 (Sca-2) expression can distinguish the most immature T-lymphocyte precursors in the thymus from the hemopoietic stem cells. Sequence analysis of the Sca-2 protein showed that Sca-2 is a glycosylphosphatidylinositol (GPI) anchored molecule that shares some characteristics with the members of the Ly-6 multigene family, and that it is the same as the thymic shared antigen-1 (TSA-1). Here we extend these studies and critically reassess the expression of the Sca-2/TSA-1 antigen in hematopoietic tissues of adult and developing mice. With more sensitive methods we show that the distribution of Sca-2/TSA-1 differs from existing reports. We find especially high expression of Sca-2/TSA1 at day 14 of fetal development. (C) 1997 Elsevier Science B.V.
Publisher: ELSEVIER SCIENCE BV
Keywords: THYMIC SHARED ANTIGEN-1; MOUSE BONE-MARROW; PRECURSOR CELLS; MONOCLONAL-ANTIBODIES; LYMPHOCYTES; DIFFERENTIATION; IDENTIFY; MOLECULE; IMMATURE; MEMBER
Publisher's Version: https://doi.org/10.1016/S0165-2478(96)02682-X
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1997-01-01 12:00:00