Synergy between TGF-beta 3 and NT-3 to promote the survival of spiral ganglia neurones in vitro

Author(s): Marzella, PL; Clark, GM; Shepherd, RK; Bartlett, PF; Kilpatrick, TJ;
Details: Publication Year 1998-01-09,Volume 240,Issue #2,Page 77-80
Journal Title: NEUROSCIENCE LETTERS
Publication Type: Journal Article
Abstract: Transforming growth factor-beta s (TGF-beta s) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-beta 3 and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-beta 3 supports neuronal survival in a concentration-dependent manner. Moreover TGF-beta 3 and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion. (C) 1998 Elsevier Science Ireland Ltd.
Publisher: ELSEVIER SCI IRELAND LTD
Keywords: ADULT AUDITORY NEURONS; GROWTH-FACTOR; EXPRESSION PATTERNS; HAIR-CELLS; NEUROTROPHINS; BETA-1; NERVE
Publisher's Version: https://doi.org/10.1016/S0304-3940(97)00928-2
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1998-01-09 12:00:00