CD4(+) T cell help impairs CD8(+) T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity
- Author(s)
- Kurts, C; Carbone, FR; Barnden, M; Blanas, E; Allison, J; Heath, WR; Miller, JFAP;
- Details
- Publication Year 1997-12-15,Volume 186,Issue #12,Page 2057-2062
- Journal Title
- JOURNAL OF EXPERIMENTAL MEDICINE
- Publication Type
- Journal Article
- Abstract
- Self-antigens expressed in extrathymic tissues such as the pancreas can be transported to draining lymph nodes and presented in a class I-restricted manner by bone marrow-derived antigen-presenting cells. Such cross-presentation of self-antigens leads to CD8(+) T cell tolerance induction via deletion. In this report, we investigate the influence of CD4(+) T cell help on this process. Small numbers of autoreactive OVA-specific CD8(+) T cells were unable to cause diabetes when adoptively transferred into mice expressing ovalbumin in the pancreatic beta cells. Coinjection of OVA-specific CD4(+) helper T cells, however, led to diabetes in a large proportion of mice (68%), suggesting that provision of help favored induction of autoimmunity. Analysis of the fate of CD8(+) T cells indicated that CD4(+) T cell help impaired their deletion. These data indicate that control of such help is critical for the maintenance of CD8(+) T cell tolerance induced by cross-presentation.
- Publisher
- ROCKEFELLER UNIV PRESS
- Keywords
- CD8+ CELLS; IN-VIVO; B-CELLS; LYMPHOCYTES; INDUCTION; ABSENCE; INVIVO; MEMORY; MICE; REQUIREMENT
- Publisher's Version
- https://doi.org/10.1084/jem.186.12.2057
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-12-15 12:00:00