Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre
- Author(s)
- Tarlinton, DM; Smith, KGC;
- Details
- Publication Year 2000-09,Volume 21,Issue #9,Page 436-441
- Journal Title
- IMMUNOLOGY TODAY
- Publication Type
- Journal Article
- Abstract
- Until recently, the relationship between apoptosis, selection in the germinal centre (GC) and production of high-affinity antibody-forming cells (AFCs) and memory B cells has been unclear. Here, Tarlinton and Smith present a model that accounts for the switch in GC production from high-affinity AFCs to memory B cells, and explain how Bcl-2, an inhibitor of apoptosis, can influence memory cells but not bone marrow AFCs.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- PRIMARY IMMUNE-RESPONSE; NEGATIVE SELECTION; BONE-MARROW; IN-SITU; CENTERS; ANTIGEN; DIFFERENTIATION; SURVIVAL; (4-HYDROXY-3-NITROPHENYL)ACETYL; LYMPHOCYTES
- Publisher's Version
- https://doi.org/10.1016/S0167-5699(00)01687-X
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2000-09-01 12:00:00