Cardiac looping - an uneasy deal with laterality

Author(s): Harvey, RP;
Details: Publication Year 1998-02,Volume 9,Issue #1,Page 101-108
Journal Title: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Publication Type: Journal Article
Abstract: Cardiac looping is a key morphogenetic went in vertebrate heart development. In a complex progression, the linear heart tube adopts a sweeping rightward curvature, establishing an architecture for the multichambered organ it soon becomes. Looping is an asymmetric event, its rightward direction being determined by an embryonic left-right axial pathway. The dextral loop has been a vehicle for development of heart complexity during evolution, to the extent that in higher vertebrates and humans, heart structure and function is extremely susceptible to perturbations of laterality, which may be common. The first clues to genetic control of laterality and looping are now emerging. Key issues to resolve include the origin of laterality information in the embryo, the exact nature of the effector molecules that link laterality to looping and the intrinsic mechanisms that drive the looping process itself.
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Keywords: LEFT-RIGHT ASYMMETRY; EMBRYONIC HEART; NODAL EXPRESSION; SITUS-INVERSUS; MOUSE EMBRYOS; CHICK-EMBRYO; FATE MAP; HANDEDNESS; DIFFERENTIATION; MORPHOGENESIS
Publisher's Version: https://doi.org/10.1006/scdb.1997.0188
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 1998-02-01 12:00:00