Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?
- Author(s)
- Kronin, V; Vremec, D; Shortman, K;
- Details
- Publication Year 1998-02,Volume 10,Issue #2,Page 237-240
- Journal Title
- INTERNATIONAL IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The IL-2 receptor (IL-2R) alpha chain (CD25), but not the IL-2R beta chain, is induced on dendritic cells (DC) by brief periods of culture. To test if this IL-2R alpha is important for DC function, DC were isolated from the spleens of mutant mice with the IL-2R alpha gene disrupted and compared with normal DC for ability to stimulate proliferation of allogeneic CD4 and CD8 T cells in culture. The IL-2R alpha null DC and the normal DC produced nearly identical proliferative responses from CD4 and from CD8 T cells. When the CD8 alpha(+) and CD8 alpha(-) subsets of the IL-2R alpha null DC were separated, they also produced proliferative responses similar to that of their normal DC counterparts. Overall there was no evidence that the inducible IL-2R alpha on DC was required for DC development, for stimulation of T cells or for regulation of T cell responses.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- SURFACE MARKER ANALYSIS; INTERLEUKIN-2 RECEPTORS; MONOCLONAL-ANTIBODIES; LANGERHANS CELLS; T-CELLS; EXPRESSION; SUBCLASS; ANTIGENS; THYMUS; SPLEEN
- Publisher's Version
- https://doi.org/10.1093/intimm/10.2.237
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-02-01 12:00:00