The Bcl-2 family and cell death regulation
- Author(s)
- Newton, K; Strasser, A;
- Details
- Publication Year 1998-02,Volume 8,Issue #1,Page 68-75
- Journal Title
- CURRENT OPINION IN GENETICS & DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- Members of the Bcl-2 protein family fall into two categories on the basis of their ability to either promote or suppress apoptosis. Recent findings have linked these proteins to caspases, the cysteine proteases that effect the collapse of the cell via binding to CED-4. It seems that Bcl-2 proteins influence cell survival by regulating the activation of key caspases.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- CAENORHABDITIS-ELEGANS; C-ELEGANS; ENDOPLASMIC-RETICULUM; NUCLEAR-ENVELOPE; HOMOLOG BAK; E1B 19K; B-CELLS; APOPTOSIS; PROTEIN; GENE
- Publisher's Version
- https://doi.org/10.1016/S0959-437X(98)80064-6
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-02-01 12:00:00