A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
- Author(s)
- Newton, K; Harris, AW; Bath, ML; Smith, KGC; Strasser, A;
- Details
- Publication Year 1998-02-02,Volume 17,Issue #3,Page 706-718
- Journal Title
- EMBO JOURNAL
- Publication Type
- Journal Article
- Abstract
- Members of the tumour necrosis factor receptor family that contain a death domain have pleiotropic activities. They induce apoptosis via interaction with intracellular FADD/MORT1 and trigger cell growth or differentiation via TRADD and TRAF molecules. The impact of FADD/MORT1-transduced signals on T lymphocyte development was investigated in transgenic mice expressing a dominant negative mutant protein, FADD-DN, Unexpectedly, FADD-DN enhanced negative selection of self-reactive thymic lymphocytes and inhibited T cell activation by increasing apoptosis, Thus signalling through FADD/MORT1 does not lead exclusively to cell death, but under certain circumstances can promote cell survival and proliferation.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- TUMOR-NECROSIS-FACTOR; RECEPTOR TRANSGENIC MICE; PROGRAMMED CELL-DEATH; KAPPA-B ACTIVATION; NEGATIVE SELECTION; TNF RECEPTOR; FAS ANTIGEN; CD4(+)CD8(+) THYMOCYTES; INDUCED APOPTOSIS; BCL-2 TRANSGENE
- Publisher's Version
- https://doi.org/10.1093/emboj/17.3.706
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1998-02-02 12:00:00