Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community study
- Author(s)
- AlYaman, F; Genton, B; Reeder, JC; Anders, RF; Smith, T; Alpers, MP;
- Details
- Publication Year 1997-09,Volume 91,Issue #5,Page 602-605
- Journal Title
- TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
- Publication Type
- Journal Article
- Abstract
- A prospective community study in a highly malaria endemic area of Papua New Guinea found that infection with multiple Plasmodium falciparum genotypes was an indicator of lowered risk of subsequent clinical attack. The results suggest that concurrent or very recent infections provide protection from superinfecting parasites. The finding of an association between reduced risk of clinical malaria and infection with parasites of merozoite surface protein 1 (MSP-1) type R033 or MSP-2 type 3D7 further suggests that the concomitant immunity is, at least in part, a consequence of a response to these major merozoite surface proteins.
- Publisher
- ROYAL SOC TROPICAL MEDICINE
- Keywords
- EAST SEPIK PROVINCE; PAPUA-NEW-GUINEA; VACCINE TRIALS; WOSERA AREA; MORBIDITY; IMMUNITY; EPIDEMIOLOGY; MORTALITY; PARASITES; MSA-2
- Publisher's Version
- https://doi.org/10.1016/S0035-9203(97)90046-8
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-09-01 12:00:00