Interferon regulatory factor 1 is induced by interferon-gamma equally in neurons and glial cells
- Author(s)
- Thomas, HE; Dutton, R; Bartlett, PF; Kay, TWH;
- Details
- Publication Year 1997-09,Volume 78,Issue #1-2,Page 132-137
- Journal Title
- JOURNAL OF NEUROIMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Class I MHC protein is induced in glia but not mature neurons by IFN-gamma. We have compared IFN-gamma signal transduction in these populations. There were identical levels of STAT1 homodimers and IRF-1 by gel-shift and IRF-1 mRNA was induced equally. However class I MHC, beta 2-microglobulin and interleukin 1-beta converting enzyme mRNA levels were greatly reduced in neurons. These experiments show that there is no defect in expression of IRF-1 in response to IFN-gamma in mature mouse neurons but that insufficient class I MHC gene expression is induced for detectable cell surface protein expression. (C) 1997 Elsevier Science B.V.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- MHC CLASS-I; NF-KAPPA-B; BETA-2-MICROGLOBULIN GENE-EXPRESSION; APOPTOSIS; ANTIGENS; BRAIN; TRANSCRIPTION; INDUCTION; SEQUENCES; BINDING
- Publisher's Version
- https://doi.org/10.1016/S0165-5728(97)00091-X
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-09-01 12:00:00