Factors involved in leukaemogenesis and haemopoiesis
- Author(s)
- Elefanty, AG; Robb, L; Begley, CG;
- Details
- Publication Year 1997-09,Volume 10,Issue #3,Page 589-614
- Journal Title
- BAILLIERES CLINICAL HAEMATOLOGY
- Publication Type
- Journal Article
- Abstract
- This review describes the chromosomal abnormalities in T-cell acute lymphoblastic leukaemia (ALL) which result in the over-expression of the gene SCL, which encodes a helix-loop-helix transcription factor. Also described are how gene targeting studies have revealed a key role for SCL in normal haemopoiesis. Next, the BCR-ABL fusion protein, seen in chronic myeloid leukaemia (CML) and in some patients with ALL, is discussed. Finally, the involvement of members of the core-binding factor (CBF) gene family in leukaemogenesis are described. Members of this gene family are involved in the generation of fusion proteins as a result of t(8;21) and inv(16), the most common translocations associated with acute myeloid leukaemia (AML). They provide a useful model of the way in which aberrant transcriptional function, brought about through genetic alterations, can modify haemopoietic development.
- Publisher
- BAILLIERE TINDALL
- Keywords
- ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; T-CELL LEUKEMIA; LOOP-HELIX PROTEINS; ACUTE LYMPHOCYTIC-LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; BCR-ABL ONCOGENE; DNA-BINDING ACTIVITY; SCL GENE-PRODUCT; TRANSFORMED HEMATOPOIETIC-CELLS
- Publisher's Version
- https://doi.org/10.1016/S0950-3536(97)80028-5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-09-01 12:00:00