Outcome of rheumatoid arthritis and psoriasis following autologous stem cell transplantation for hematologic malignancy
- Author(s)
- Cooley, HM; Snowden, JA; Grigg, AP; Wicks, IP;
- Details
- Publication Year 1997-09,Volume 40,Issue #9,Page 1712-1715
- Journal Title
- ARTHRITIS AND RHEUMATISM
- Publication Type
- Journal Article
- Abstract
- Based on successful results in animal models, it has been proposed that high-dose myeloablative therapy followed by autologous bone marrow or stem cell transplantation (ABMT/ASCT) may cure autoimmune disease, The coexistence of autoimmune disease and hematologic malignancy provides an opportunity to examine the response of autoimmune disease to ABMT or ASCT. We describe 4 patients with autoimmune disease (3 with psoriasis and 1 with rheumatoid arthritis) and hematologic malignancy, In each patient, the autoimmune disease remitted posttransplantation, but, in 4 patients with long-term followup, it recurred at 8-24 months, The earliest relapse occurred in a patient treated with interferon-alpha. Our experience suggests that a single autograft with unpurged stem cells is unlikely to cure autoimmune disease, but that other strategies building on this approach are worthy of investigation.
- Publisher
- LIPPINCOTT-RAVEN PUBL
- Keywords
- BONE-MARROW TRANSPLANTATION; AUTOIMMUNE-DISEASES; MYELOGENOUS LEUKEMIA; T-CELL; REMISSION; INDUCTION
- Publisher's Version
- https://doi.org/10.1002/art.1780400923
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-09-01 12:00:00