The SCL/TAL1 gene: Roles in normal and malignant haematopoiesis
- Author(s)
- Robb, L; Begley, CG;
- Details
- Publication Year 1997-07,Volume 19,Issue #7,Page 607-613
- Journal Title
- BIOESSAYS
- Publication Type
- Journal Article
- Abstract
- SCL (TAL1/TCL5) is a member of the helix-loop-helix family of transcription factors. Originally identified because of its involvement in a tumour-specific chromosomal translocation, overexpression of the SCL gene is the most common molecular abnormality found in human T cell leukaemia. Transgenic models have now formally demonstrated that overexpression of SCL within the T cell lineage is capable of causing malignant transformation. Gene targeting experiments have revealed that the SCL gene is crucial for the development of primitive haematopoiesis in the mouse and is also required for the generation of all adult haematopoietic lineages. Biochemical studies have indicated some of the proteins which interact with SCL and this has refined the hypotheses concerning the mechanisms by which SCL plays a role in leukaemogenesis and haematopoietic development.
- Publisher
- COMPANY OF BIOLOGISTS LTD
- Keywords
- T-CELL LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; LOOP-HELIX PROTEINS; PEDIATRIC-ONCOLOGY-GROUP; SITE-SPECIFIC DELETIONS; DNA-BINDING MOTIF; ERYTHROID-DIFFERENTIATION; TRANSCRIPTION FACTORS; TAL-1 GENE; SCL GENE
- Publisher's Version
- https://doi.org/10.1002/bies.950190711
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-07-01 12:00:00