The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias
Author(s)
Metcalf, D;
Details
Publication Year 1997-10,Volume 11,Issue #10,Page 1599-1604
Journal Title
LEUKEMIA
Publication Type
Journal Article
Abstract
The transformation of normal hematopoietic cells to leukemic cells requires cells to acquire two intrinsic changes. These are the acquisition by some method of autocrine growth stimulation and a perturbation of differentiation commitment leading to abnormal levels of self-generation. Hematopoietic regulator action can be involved to produce or facilitate both these changes but the same regulators can also suppress some leukemic populations by enforced differentiation commitment.
Publisher
STOCKTON PRESS
Keywords
COLONY-STIMULATING FACTOR; ACUTE MYELOBLASTIC-LEUKEMIA; IRRADIATED RECIPIENT MICE; FACTOR-DEPENDENT CELLS; HOX-2.4 HOMEOBOX GENE; GM-CSF; CLONAL ANALYSIS; MYELOPROLIFERATIVE SYNDROME; ERYTHROPOIETIN RECEPTOR; AUTONOMOUS GROWTH
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 1997-10-01 12:00:00
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