Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage
- Author(s)
- Wu, L; Nichogiannopoulou, A; Shortman, K; Georgopoulos, K;
- Details
- Publication Year 1997-10,Volume 7,Issue #4,Page 483-492
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- The transcription factor Ikaros is a major determinant of lymphocyte differentiation. Mice homozygous for an Ikaros dominat-negative (DN-/-) mutation lack all cells of lymphoid origin, including T, B, and natural killer (NK) cells. Mice homozygous for an Ikaros null allele lack B and NK cells but display specific defects in T lymphocytes. Nonetheless, both Ikaros mutant lines make an excess of monocytes and macrophages. Here we report that the production of subsets of antigen-presenting dendritic cells (DCs) is also defective. By constructing bone marrow chimeras, we demonstrate that the Ikaros-mediated defect in lymphocytes and DCs is intrinsic to their precursors and is not environment dependent. The selective defects in DCs manifested with the Ikaros null mutation suggest a tight linkage between development of T cells and CD8 alpha(+) DCs. The complete lack of DCs in the lymphoid organs of Ikaros DN-/- micke points to an essential role for the Ikaros gene family in the development of all DCs.
- Publisher
- CELL PRESS
- Keywords
- COLONY-STIMULATING FACTOR; PRECURSOR CELLS; MOUSE THYMUS; TRANSCRIPTION FACTOR; CD8 EXPRESSION; TNF-ALPHA; T-CELLS; GENE; COMMITMENT; LIGAND
- Publisher's Version
- https://doi.org/10.1016/S1074-7613(00)80370-2
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 1997-10-01 12:00:00